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Tumor M2-PK:
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a tool for metabolic profiling of colorectal tumors
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Staining of a rectal carcinoma
with monoclonal antibodies against Tumor M2-PK
The normal rectal mucosa is not stained with the Tumor M2-PK specific antibody whereas the carcinoma is Tumor M2-PK positive.
The Tumor M2-PK staining of primary tumors is usually heterogeneous whereas their metastases are always very homogeneously stained.
Staining of a liver metastasis
from rectal carcinoma
with monoclonal antibodies against tumor M2-PK
Vmax activities were measured spectrophotometrically according to the following reaction:
Tumor M2-PK measurements in stool and EDTA-plasma samples:
Hans-Ulrich Klör
Philip D. Hardt
Tumor M2-PK concentrations were measured with a sandwich ELISA from ScheBo Biotech AG Giessen, Germany.
References
Tumor M2-PK: clinical relevance for metabolic profiling of tumors
Metabolic tools for tumor diagnosis
Pyruvate kinase isoenzymes: M2-PK
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