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M2-PK: metabolic consequences of the tetrameric form
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Animation
Explanation:
When M2-PK (PKM2) is in the highly active tetrameric form glucose is converted to lactate under the production of energy.
In consequence:
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ADP and GDP levels are low
(= substrates of PK).
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ATP and GTP levels are high
(= products of the PK reaction).
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Phosphometabolite levels are low (= intermediates of glycolysis).
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Rates of synthetic processes
are low.
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Levels of cell building material such as UTP and CTP are low.
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(ATP+GTP) : (UTP+CTP) ratio is high.
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References
Metabolic consequences of the dimeric form
Pyruvate Kinase isoenzymes : M2-PK
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