metabolic consequences of the tetrameric form



When M2-PK (PKM2) is in the highly active tetrameric form glucose is converted to lactate under the production of energy.

In consequence:

  • ADP and GDP levels are low
    (= substrates of PK).
  • ATP and GTP levels are high
    (= products of the PK reaction).
  • Phosphometabolite levels are low (= intermediates of glycolysis).
  • Rates of synthetic processes are low.
  • Levels of cell building material such as UTP and CTP are low.
  • (ATP+GTP) : (UTP+CTP) ratio is high.