metabolic consequences of the tetrameric form

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Explanation:

When M2-PK (PKM2) is in the highly active tetrameric form glucose is converted to lactate under the production of energy.

In consequence:

• ADP and GDP levels are low
  (= substrates of PK).
• ATP and GTP levels are high
  (= products of the PK reaction).
• Phosphometabolite levels are low (= intermediates of glycolysis).
• Rates of synthetic processes are low.
• Levels of cell building material such as UTP and CTP are low.
• (ATP+GTP) : (UTP+CTP) ratio is high.