Solid tumors are characterized by large fluctuations in oxygen supply. Due to tumor size and vascularization, normoxic and hypoxic areas occur within the same tumor. Hypoxia selects tumor cells which are able to survive under low oxygen supply and to metastasize. Therefore, a large amount of hypoxic areas within a tumor correlates with a poor prognosis. Metabolic strategies of tumors for survival under low oxygen supply Glutaminolysis and the truncated citrate cycle |
