PKM2: a target of the pp60^v-src kinase

The pp60^v-src kinase is the transforming principle of the Rous Sarcoma Virus. The pp60^v-src kinase, a protein with a molecular weight of 60 kDa, is phosphorylated in serine and has tyrosine kinase specific activity. One of the substrates of the pp60^v-src kinase is M2-PK (PKM2).

Phosphorylation of M2-PK in tyrosine by the pp60^v-src kinase leads to:

• A dimerization of M2-PK and
• an increase of phosphometabolite levels due to the inactivation of M2-PK