PKM2: Differentiation between Lung M2-PK and Tumor M2-PK

The M2-PK isoenzyme found in lung tissues is always tetrameric The M2-PK isoenzyme found in lung tissues is always tetrameric.

The M2-PK isoenzyme found in tumor cells is mainly dimeric The M2-PK isoenzyme found in tumor cells is mainly dimeric.

Therefore, the dimeric form of M2-PK has been termed tumor M2-PK.