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Anaerobic glycolysis:
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as a metabolic strategy of tumors for
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survival under low oxygen supply
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The conversion of glucose to lactate in the absence of oxygen has been termed anaerobic glycolysis.
Glycolysis provides 2 moles of ATP per mole of glucose.
The enzyme responsible for net ATP production is pyruvate kinase.
The hydrogen that is produced by the glycolytic glyceraldehyde 3-P dehydrogenase reaction is excreted as lactate.
Metabolic scheme
All tumor cells possess large amounts of glycolytic enzymes.
Therefore, at low oxygen pressure energy production is possible via glycolysis.
References
Aerobic glycolysis
Metabolic strategies of tumors for survival under low
oxygen supply
Oxygen: main page
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