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M2-PK: Kinetic characteristics
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Pyruvate kinase type M2-PK can occur in a tetrameric form with a high affinity for its substrate phosphoenolpyruvate and in a dimeric form with a low affinity for phosphoenolpyruvate.
Metabolic intermediates and oncoproteins regulate the tetramer : dimer ratio of M2-PK (PKM2).
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Metabolic consequences (animation)
References
Pyruvate Kinase isoenzymes : M2-PK
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