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Glycolysis: isoenzyme equipment
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When Otto Warburg discovered that tumor cells produce high levels of lactate even in the presence of oxygen around 1920 he thought that a defect in mitochondrial respiration would be the cause of the so called aerobic glycolysis. Such a defect could never been demonstrated.
Today it is generally accepted that a shift in the isoenzyme equipment of distinct glycolytic enzymes is the main cause of the increased aerobic glycolysis in tumor cells.
References
Glycolysis : main page
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